2-Chlorotoluene → 1,3-Isobenzofurandione, 5-fluoro-
反応式
[F:1][C:2]1(F)[CH2:12][CH2:11][CH:5]2[C:6]([O:8][C:9](=[O:10])[CH:4]2[CH2:3]1)=[O:7].ClC1C=CC=CC=1C>[Pd]>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1参加物
4
実験手順
A mixture of 500 parts of 4,4-difluorohexahydrophthalic anhydride and 100 parts of 5 percent Pd/C catalyst in 3787 parts of o-chlorotoluene was charged to an autoclave reactor. The autoclave atmosphere was purged with nitrogen. The autoclave when then sealed, heated to 300°-350° and maintained thereat for about 3 hours, then cooled to about room temperature. Analysis of the reaction product, by gas chromatographic techniques indicated a 37 percent yield of 4-fluorophthalic anhydride, based on the difluorohexahydrophthalic anhydride reactant.
後処理
- additionwas charged to an autoclave reactor
- customThe autoclave atmosphere was purged with nitrogen
- customThe autoclave when then sealed
- temperatureheated to 300°-350°
- temperaturemaintained
- temperaturecooled to about room temperature
出典と根拠
- ORDレコード
- ord-40179c84082049ed9cdd852cdd4a12ac
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04517372
反応ノート
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