Glutaric Acid → N-[4-(3-aminopropyl)aminobutyl]-2-(9-guanidino-2-nonenamido)-2-hydroxyethanamide

HRID 462916

反応式

HRID 462916 の反応式
Cl.[NH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]=[CH:13][C:14]([NH2:16])=[O:15])[C:3]([NH2:5])=[NH:4].Cl.Cl.[NH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:29](=[O:33])[CH:30](O)[OH:31].C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.N(CCCCCCC=CC(NC(O)C(N)=O)=O)C(N)=N>O>[NH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:29](=[O:33])[CH:30]([NH:16][C:14](=[O:15])[CH:13]=[CH:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:2][C:3]([NH2:5])=[NH:4])[OH:31]

参加物

6

反応物 4

HCID 743Glutaric AcidHCID 133564GlyoxylylspermidineHCID 178478605HCID 178478605、化合物HCID 178479425HCID 178479425、化合物

生成物 1

HCID 178512796N-[4-(3-aminopropyl)aminobutyl]-2-(9-guanidino-2-nonenamido)-2-hydroxyethanamide収率 38.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

A mixture of 206.2 mg (0.84 mmole) of 9-guanidino-2-nonenamide hydrochloride, 291.0 mg (1.00 mmole) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 109.6 mg (0.84 mmole) of glutaric acid and 0.2 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, the reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 135.0 mg (31.1% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(9-guanidino-2-nonenamido-2-hydroxyethanamide trihydrochloride.

後処理

  1. customAfter completion of the reaction
  2. customthe reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex®

出典と根拠

ORDレコード
ord-dc615805a55a42cf8a30f6d2f2018da6
出典データセット
uspto-grants-1985_05
特許番号
US04518532

関連ノート

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