Sodium Hydroxide → [2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone

HRID 463027

反応式

HRID 463027 の反応式
[CH3:1][N:2]([CH3:30])[CH2:3][CH2:4][CH2:5][N:6]([C:21]1[C:26]([N+:27]([O-])=O)=[CH:25][CH:24]=[CH:23][N:22]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14].[OH-].[Na+]>C(O)C.O.[Zn]>[CH3:30][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][N:6]([C:21]1[C:26]([NH2:27])=[CH:25][CH:24]=[CH:23][N:22]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:14]

参加物

6

反応物 2

HCID 14798Sodium HydroxideHCID 54525496[2-[[3-(Dimethylamino)propyl](3-nitro-2-pyridinyl)amino]phenyl]phenylmethanone

生成物 1

HCID 53769600[2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone

試薬・触媒・溶媒 3

HCID 23994Zinc触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of (0.05 mole) [2-[[3-(dimethylamino)propyl](3-nitro-2-pyridinyl)amino]phenyl]phenylmethanone, 13 g, (0.20 mole) of zinc dust, 2 g (0.05 mole) of sodium hydroxide in 75 ml ethanol and 25 ml water is stirred under reflux for 1 hr. The mixture is filtered and evaporated under reduced pressure. The residue is dissolved in methylene chloride and the resulting solution is dried over magnesium sulfate and decolorized with charcoal and filtered. The filtrate is evaporated to dryness and to give the title compound in crude mixture.

後処理

  1. temperatureunder reflux for 1 hr
  2. filtrationThe mixture is filtered
  3. customevaporated under reduced pressure
  4. dissolutionThe residue is dissolved in methylene chloride
  5. dry with materialthe resulting solution is dried over magnesium sulfate
  6. filtrationfiltered
  7. customThe filtrate is evaporated to dryness

出典と根拠

ORDレコード
ord-84544717d0a64aa1b8919cc724576681
出典データセット
uspto-grants-1985_05
特許番号
US04518603

関連ノート

読み込み中…