Hydrogen Bromide → HCID 10036524、化合物

反応式

C(O[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])(=O)C.O.[BrH:16]>>[Br:16][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11]

参加物

反応物 3

HCID 260Hydrogen Bromide

HCID 962Water

HCID 202819056-Acetoxy-2,2-dimethylhexanoic acid

生成物 1

HCID 10036524HCID 10036524、化合物収率 91%

反応条件

温度: 130 °C

実験手順

6-Acetoxy-2,2-dimethylhexanoic acid (4.5 g) was dissolved in 47% aqueous hydrobromic acid (25 ml), and the solution was heated at 130° C. for 4 hours. After the completion of the reaction, water (100 ml) was added to the solution, and the product was extracted with ether. The organic layer was washed with water, dried and concentrated under reduced pressure. The residue was chromatographed on a column of silica gel, and development with isopropyl ether yielded 6-bromo-2,2-dimethylhexanoic acid (4 g, 91%).

後処理

additionwas added to the solution
extractionthe product was extracted with ether
washThe organic layer was washed with water
customdried
concentrationconcentrated under reduced pressure
customThe residue was chromatographed on a column of silica gel, and development with isopropyl ether

出典と根拠

ORDレコード: ord-e4cfa8b1063441a49398f0ae5e38d391
出典データセット: uspto-grants-1985_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04518602

反応ノート

読み込み中…

参加物