5-Methoxy-2-nitrobenzaldehyde → (2-Amino-5-methoxyphenyl)methanol

HRID 463059

反応式

HRID 463059 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-])=O)=[C:7]([CH:10]=1)[CH:8]=[O:9].[H][H]>CO.[Ni]>[NH2:11][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:10][C:7]=1[CH2:8][OH:9]

参加物

5

反応物 2

HCID 2303715-Methoxy-2-nitrobenzaldehydeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 13756678(2-Amino-5-methoxyphenyl)methanol

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A quantity of 181.2 gm (1 mol) of 5-methoxy-2-nitrobenzaldehyde (prepared by methylation of 2-nitro-5-hydroxy-benzaldehyde with methyl iodide/potassium tert.-butoxide in dimethylsulfoxide) is dissolved in 1.8 liters of methanol, mixed with 50 gm of Raney nickel, and hydrogenated at ambient temperature and at 5 bar. After ten hours, the hydrogen uptake has ended. The catalyst is removed by suction filtration, and the methanol is distilled off.

後処理

  1. customhydrogenated at ambient temperature
  2. waitAfter ten hours
  3. customThe catalyst is removed by suction filtration
  4. distillationthe methanol is distilled off

出典と根拠

ORDレコード
ord-03aee2ce438b454aa75f4a46a9749cfa
出典データセット
uspto-grants-1985_05
特許番号
US04518597

関連ノート

読み込み中…