Benzoic acid, 3-methoxy-2-nitro-, methyl ester → Methyl 2-amino-3-methoxybenzoate

HRID 463065

反応式

HRID 463065 の反応式
[CH3:1][O:2][C:3]1[C:4]([N+:13]([O-])=O)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7]>C1(C)C=CC=CC=1.[Pt]>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[C:4]=1[NH2:13]

参加物

4

反応物 1

HCID 79195Benzoic acid, 3-methoxy-2-nitro-, methyl ester

生成物 1

HCID 602320Methyl 2-amino-3-methoxybenzoate

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 1140Toluene溶媒

実験手順

One hundred thirty-three grams (0.63 mol) of methyl 3-methoxy-2-nitro-benzoate are dissolved in 1000 ml of toluene and hydrogenated in an autoclave at ambient temperature and under a hydrogen pressure of 5 bar in the presence of platinum over a period of two hours. The catalyst is removed by filtration, the residue is dried with sodium sulfate, and the toluene is distilled off in vacuo. Oil, RF value: 0.8 [silica gel plate; chloroform/acetone (9:1)],

後処理

  1. customhydrogenated in an autoclave at ambient temperature and under a hydrogen
  2. customof two hours
  3. customThe catalyst is removed by filtration
  4. dry with materialthe residue is dried with sodium sulfate
  5. distillationthe toluene is distilled off in vacuo

出典と根拠

ORDレコード
ord-b6f69015d892488a930568c8d1363b2b
出典データセット
uspto-grants-1985_05
特許番号
US04518597

関連ノート

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