Hydrochloric Acid → (1-methyl-1H-pyrazol-5-yl)boronic acid

To a stirred solution of 1-methyl-1H-pyrazole (2.49 mL, 30 mmol) in tetrahydrofuran (100 mL) was added butyllithium (2.5 M in hexane, 15.6 mL, 39 mmol) at −78° C. dropwise. After stirring for 1 hour, triisopropyl borate (27.6 mL, 120 mmol) was added and the reaction mixture was gradually warmed to room temperature for 16 hours. Hydrochloric acid (1 N aqueous solution) was added to the reaction mixture until pH 7 achieved. The mixture was extracted with dichloromethane:methanol (9:1, 5×200 mL). Combined organic extracts were dried over magnesium sulphate and concentrated in vacuo to obtain crude residue. Purification was undertaken by flash column chromatography (ISCO™) eluting with dichloromethane:methanol (7:3, by volume) to afford the title compound as a white solid, 1258 mg, 33% yield.

1. extractionThe mixture was extracted with dichloromethane:methanol (9:1, 5×200 mL)
2. dry with materialCombined organic extracts were dried over magnesium sulphate
3. concentrationconcentrated in vacuo
4. customto obtain crude residue
5. customPurification
6. washeluting with dichloromethane:methanol (7:3, by volume)

ORDレコード

ord-d10a93e5238f4cc7a481ac6945dcec4e

出典データセット

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08541588B2