Ammonium Chloride → 4'-Chloro-3-phenylpropiophenone

HRID 463512

反応式

HRID 463512 の反応式
[C:1]1([CH2:7][CH2:8][C:9](Cl)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([Mg]Br)=[CH:15][CH:14]=1.[Cl-].[NH4+]>C1C=CC=CC=1.[Cl-].[Cd+2].[Cl-]>[C:1]1([CH2:7][CH2:8][C:9]([C:16]2[CH:17]=[CH:18][C:13]([Cl:12])=[CH:14][CH:15]=2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 25517Ammonium ChlorideHCID 64801Benzenepropanoyl chlorideHCID 178478191HCID 178478191、化合物

生成物 1

HCID 2473444'-Chloro-3-phenylpropiophenone収率 58%

試薬・触媒・溶媒 2

HCID 24633Cadmium chloride, dihydrate触媒HCID 241Benzene溶媒2 回

実験手順

Phenylpropionyl chloride (33.7 g) in benzene was added dropwise to a stirred mixture of 4-chlorophenyl magnesium bromide (derived from 38 g of 4-chlorobromobenzene) and cadmium chloride (37 g) in benzene at 0°. The mixture was stirred at room temperature for 6 hours and aqueous ammonium chloride solution then added. Ether extraction yielded p-chlorophenyl phenylethyl ketone (25 g) m.p. 78°-79°.

後処理

  1. extractionEther extraction

出典と根拠

ORDレコード
ord-61dbe1b7ada641c0b901f2e585d9aef7
出典データセット
uspto-grants-1985_05
特許番号
US04520007

関連ノート

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