Sodium Hydroxide → 4-[(Methylsulfonyl)amino]benzoic acid sodium salt

HRID 463672

反応式

HRID 463672 の反応式
[OH-].[Na+:2].[CH3:3][S:4]([NH:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]>O>[Na+:2].[CH3:3][S:4]([NH:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([O-:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2506534-(Methylsulfonamido)benzoic acid

生成物 1

HCID 236984714-[(Methylsulfonyl)amino]benzoic acid sodium salt収率 97.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 500 ml of water is added 63.4 g (1.59 mole) of sodium hydroxide and the mixture is stirred until all the solid has dissolved. To this is slowly added 310 g (1.44 mole) of 4-[(methylsulfonyl)amino]benzoic acid. The reaction is stirred for 15 minutes at ambient temperature after all the solid has dissolved. After removal of the water in vacuo, the residue is triturated with isopropyl alcohol, evaporated, triturated with acetone and concentrated in vacuo. The solid is dried under vacuum for 72 hours to provide 333.7 g of the title compound.

後処理

  1. dissolutionhas dissolved
  2. stirringThe reaction is stirred for 15 minutes at ambient temperature after all the solid
  3. dissolutionhas dissolved
  4. customAfter removal of the water in vacuo
  5. customthe residue is triturated with isopropyl alcohol
  6. customevaporated
  7. customtriturated with acetone
  8. concentrationconcentrated in vacuo
  9. customThe solid is dried under vacuum for 72 hours

出典と根拠

ORDレコード
ord-d3aec6aa7e4f4b75b813675422581f18
出典データセット
uspto-grants-1985_10
特許番号
US04544654

関連ノート

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