N,N-Diethylethylenediamine → HCID 20225376、化合物
反応式
[CH2:1]([S:3]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:13])=[O:12])=[CH:9][CH:8]=1)(=[O:5])=[O:4])[CH3:2].[CH2:16]([N:18]([CH2:22][CH3:23])[CH2:19][CH2:20][NH2:21])[CH3:17]>C1COCC1>[ClH:13].[CH2:16]([N:18]([CH2:22][CH3:23])[CH2:19][CH2:20][NH:21][C:11](=[O:12])[C:10]1[CH:14]=[CH:15][C:7]([NH:6][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:8][CH:9]=1)[CH3:17]参加物
4
反応条件
- 温度
- -10 °C
実験手順
Dissolve 4.97 g (0.22 moles) 4-[(ethylsulfonyl)amino]benzoyl chloride in 25 ml THF. Stir under N2 at -10° C. To the solution add 3.0 ml (0.22 mole) N,N-diethylethylenediamine dropwise. Follow the progress of the reaction by thin layer chromatography on silica gel (acetonitrile:methanol:ammonium hydroxide, 85:10:5). When the reaction is complete, remove the solvents in vacuo. Dissolve the gummy residue in refluxing ethanol and chill to produce white crystals. Filter the precipitate to obtain the title compound.