Triethylamine → 1-[(5-Amino-1,3,4-thiadiazol-2-yl)amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol

HRID 4637

反応式

HRID 4637 の反応式
Br[C:2]1[S:6][C:5]([NH2:7])=[N:4][N:3]=1.C(N(CC)CC)C.[NH2:15][CH2:16][CH:17]([OH:33])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH:21]=1>C1COCC1>[NH2:7][C:5]1[S:6][C:2]([NH:15][CH2:16][CH:17]([OH:33])[CH2:18][O:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[CH:21]=2)=[N:3][N:4]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 131898251-Amino-3-{3-[(piperidin-1-yl)methyl]phenoxy}propan-2-ol

生成物 1

HCID 136573661-[(5-Amino-1,3,4-thiadiazol-2-yl)amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.54 g (3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amine and 0.45 ml of triethylamine are added to 0.8 g (3 mmol) of 1-amino-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol in 20 ml of THF and the mixture is reacted in a manner analogous to Example 51. The oil obtained is purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95)).

後処理

  1. customthe mixture is reacted in a manner analogous to Example 51
  2. customThe oil obtained
  3. customis purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95))

出典と根拠

ORDレコード
ord-6a7ed01635ed4c138cea3a4b01da5ca5
出典データセット
uspto-grants-1988_02
特許番号
US04727081

関連ノート

読み込み中…