Thionyl Chloride → [(3,5,6-Trichloropyridin-2-yl)oxy]acetyl chloride

HRID 463701ノート

反応式

HRID 463701 の反応式
[Cl:1][C:2]1[C:3]([O:10][CH2:11][C:12]([OH:14])=O)=[N:4][C:5]([Cl:9])=[C:6]([Cl:8])[CH:7]=1.S(Cl)([Cl:17])=O>C(Cl)Cl.CN(C)C=O>[Cl:1][C:2]1[C:3]([O:10][CH2:11][C:12]([Cl:17])=[O:14])=[N:4][C:5]([Cl:9])=[C:6]([Cl:8])[CH:7]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 41428Triclopyr

生成物 1

HCID 13491111[(3,5,6-Trichloropyridin-2-yl)oxy]acetyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred slurry of 30 g (0.1237 mole) 3,5,6-trichloro-2-pyridyloxyacetic acid in 500 ml methylene chloride, 1 ml N,N-dimethylformamide was added. Then 16.2 g [10 m' (0.136 mole)] thionyl chloride was added dropwise. The mixture was refluxed 31/2 hours. The solvent was stripped in vacuo to give the 3,5,6-trichloro-2-pyridyloxyacetyl chloride as an oil, which was used in step (b) without further isolation.

後処理

  1. temperatureThe mixture was refluxed 31/2 hours

出典と根拠

ORDレコード
ord-c1819414dc1d4110a01c3e9f2e876466
出典データセット
uspto-grants-1985_10
特許番号
US04544661

反応ノート

読み込み中…