2,4,5-Trifluorobenzenesulfonyl chloride → tert-Butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamate
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10](Cl)(=[O:12])=[O:11].[C:14]([O:18][C:19](=[O:26])[NH:20][C:21]1[N:22]=[CH:23][S:24][CH:25]=1)([CH3:17])([CH3:16])[CH3:15]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10]([N:20]([C:21]1[N:22]=[CH:23][S:24][CH:25]=1)[C:19](=[O:26])[O:18][C:14]([CH3:17])([CH3:15])[CH3:16])(=[O:12])=[O:11]参加物
3
実験手順
The above titled compound was prepared from 2,4,5-trifluorobenzenesulfonyl chloride (5.0 g, 0.022 mol) and thiazole-4-yl-carbamic acid tert-butyl ester (Preparation 72, 4.3 g, 0.022 mol) using the method of Preparation 453 to afford the product as a white solid (6.84 g, 80%).
出典と根拠
- ORDレコード
- ord-9761d7d53afa453cb43ddbba5f9cc9ec
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541588B2