Thionyl Chloride → 2-(2,6-Dichlorophenyl)acetyl chloride

HRID 463778ノート

反応式

HRID 463778 の反応式
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH2:13][C:14]([OH:16])=O>C1(C)C=CC=CC=1>[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH2:13][C:14]([Cl:3])=[O:16]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 810582,6-Dichlorophenylacetic acid

生成物 1

HCID 27581482-(2,6-Dichlorophenyl)acetyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

30.93 g of thionyl chloride are added dropwise to a warmed, mechanically stirred mixture of 45.12 g of 2,6-dichlorophenylacetic acid in 125 ml of toluene. The reaction mixture is then maintained at reflux for 5 hrs and cooled overnight at RT. The reaction mixture is concentrated in vacuo and the concentrate dissolved in hot petroleum ether and the solids filtered. The filtrate is concentrated in vacuo to give a dark amber liquid, which is distilled to give a clear pinkish liquid.

後処理

  1. temperatureThe reaction mixture is then maintained
  2. temperatureat reflux for 5 hrs
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. dissolutionthe concentrate dissolved in hot petroleum ether
  5. filtrationthe solids filtered
  6. concentrationThe filtrate is concentrated in vacuo
  7. customto give a dark amber liquid, which
  8. distillationis distilled
  9. customto give a clear pinkish liquid

出典と根拠

ORDレコード
ord-9c6f3cc32d0b4d0190c16567badbd980
出典データセット
uspto-grants-1985_10
特許番号
US04544670

反応ノート

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