Water → HCID 13491698、化合物

HRID 463797ノート

反応式

HRID 463797 の反応式
[CH3:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:10](N(CC)CC)[CH3:11].C(Br)C.O>C1C=CC=CC=1>[CH2:10]([NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[C:8]([Cl:9])[C:2]=1[CH3:1])[CH3:11]

参加物

6

反応物 4

HCID 962WaterHCID 6332Ethyl BromideHCID 68943-Chloro-2-methylanilineHCID 8471Triethylamine

生成物 1

HCID 13491698HCID 13491698、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

In 100 ml of benzene is dissolved 14 g of 2-methyl-3-chloroaniline obtained in Reference Example 1 and, after adding 12 g of triethylamine, 13 g of ethyl bromide is added to the solution to conduct the reaction under reflux of benzene for 3 hours. After the completion of the reaction, the mixture is cooled to room temperature and shaken with 200 ml of water. The benzene layer is separated, dried over anhydrous magnesium sulfate, and concentrated. Distillation of the residue results in 12 g of N-ethyl-2-methyl-chloroaniline as the fraction of 125°-126° C./10 mmHg.

後処理

  1. customobtained in Reference Example 1
  2. additionis added to the solution
  3. customthe reaction
  4. customAfter the completion of the reaction
  5. customThe benzene layer is separated
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated
  8. distillationDistillation of the residue
  9. customresults in 12 g of N-ethyl-2-methyl-chloroaniline as the fraction of 125°-126° C./10 mmHg

出典と根拠

ORDレコード
ord-a609d273a363402e9668b69a7fb72c5d
出典データセット
uspto-grants-1985_10
特許番号
US04544747

反応ノート

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