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Water → [6-(Hydroxymethyl)pyridin-3-yl]methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Hydride | HCID 166653 | — |
| 反応物 | 2,5-Di(acetoxymethyl)pyridine | HCID 20263986 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [6-(Hydroxymethyl)pyridin-3-yl]methanol | HCID 820251 | — |
反応手順
2,5-Di(acetoxymethyl)pyridine (0.05 mole) is reduced with lithium aluminum hydride (0.025 mole) in tetrahydrofuran (50 ml.) at 0° C. with stirring. After one hour, water is added to decompose excess hydride, and the mixture is concentrated to dryness. The residue is extracted with hot isopropanol (2×60 ml.) and the extract is concentrated to dryness to give 2,5-di(hydroxymethyl) pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04546106 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-6c5e1a5b524b4b2f99b7ec93b2f076ea |
| 出典メモ | uspto-grants-1985_10 |