2-Amino-4-methoxy-6-methyl-1,3,5-triazine → Metsulfuron-methyl

HRID 464123

反応式

HRID 464123 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11](Cl)(=[O:13])=[O:12])([O:3][CH3:4])=[O:2].[CH3:15][O:16][C:17]1[N:22]=[C:21]([CH3:23])[N:20]=[C:19]([NH2:24])[N:18]=1.[O-:25][C:26]#[N:27].[Na+]>CN1CCCC1=O.C(=O)(O)[O-].[Na+]>[CH3:15][O:16][C:17]1[N:22]=[C:21]([CH3:23])[N:20]=[C:19]([NH:24][C:26]([NH:27][S:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:1]([O:3][CH3:4])=[O:2])(=[O:13])=[O:12])=[O:25])[N:18]=1

参加物

6

反応物 3

HCID 154662-Amino-4-methoxy-6-methyl-1,3,5-triazineHCID 117830Benzoic acid, 2-(chlorosulfonyl)-, methyl esterHCID 517096Sodium Cyanate

生成物 1

HCID 52999Metsulfuron-methyl収率 55%

試薬・触媒・溶媒 2

HCID 13387N-methyl-2-pyrrolidone溶媒HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
25 °C

実験手順

A slurry of 10.0 grams (0.042 moles) of 2-carbomethoxybenzenesulfonyl chloride, 5.0 grams (0.0357 moles) 4-methoxy-6-methyl-1,3,5-triazin-2-amine and 6.0 grams (0.092 moles) sodium cyanate in 60 ml N-methylpyrrolidinone was stirred 2 hours at 80° C. The reaction was cooled to 25° C., diluted with 200 ml saturated sodium bicarbonate solution, and filtered. The filtrate was acidified with dilute hydrochloric acid and the product was collected by filtration and dried to give the title compound in 55% yield. The IR spectrum of the title compound was identical to that of an authentic sample prepared as taught in U.S. Pat. No. 4,383,113.

後処理

  1. filtrationfiltered
  2. filtrationthe product was collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-b7c299a9824f4439972a45dd4673639e
出典データセット
uspto-grants-1985_10
特許番号
US04546179

関連ノート

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