Bromine → 3-Bromo-5-(trifluoromethyl)pyridin-2(1H)-one
反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1.[Br:12]Br>C(O)(=O)C>[Br:12][C:5]1[C:6](=[O:9])[NH:7][CH:8]=[C:3]([C:2]([F:1])([F:10])[F:11])[CH:4]=1参加物
4
実験手順
0.4 g of 5-trifluoromethyl-2-pyridone was dissolved in 10 ml of acetic acid, and 0.4 g of bromine was added to the solution which was subsequently reacted for 4 hours while stirring. After completion of the reaction, the acetic acid was distilled off, and recrystallization was carried out from a mixed solvent of methylene chloride and n-hexane to obtain 0.45 g of the titled compound having a melting point of 162° to 165° C.
後処理
- customwas subsequently reacted for 4 hours
- customAfter completion of the reaction
- distillationthe acetic acid was distilled off
- customrecrystallization
出典と根拠
- ORDレコード
- ord-e3812815ec9d471faee9967cbaf14091
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04546191
反応ノート
読み込み中…