Hydrochloric Acid → 3-Chloro-5-(trifluoromethyl)pyridin-2-ol

HRID 464130

反応式

HRID 464130 の反応式
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[OH-:13].[K+].Cl>C(O)(C)(C)C>[Cl:8][C:7]1[C:2](=[O:13])[NH:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

生成物 1

HCID 7254363-Chloro-5-(trifluoromethyl)pyridin-2-ol収率 75.3%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

4.5 g of 2,3-dichloro-5-trifluoromethylpyridine was added to a solution of 2.7 g of potassium hydroxide dissolved in 40 ml of t-butanol, and the mixture was reacted at the reflux temperature for one hour while stirring. After completion of the reaction, the reaction product was allowed to cool and made acidic with concentrated hydrochloric acid. The contents were concentrated under reduced pressure to obtain a solid which was then purified to obtain 3.1 g of the titled compound having a melting point of 165° to 166° C.

後処理

  1. customthe mixture was reacted at the reflux temperature for one hour
  2. customAfter completion of the reaction
  3. temperatureto cool
  4. concentrationThe contents were concentrated under reduced pressure
  5. customto obtain a solid which
  6. customwas then purified

出典と根拠

ORDレコード
ord-3a6e9ed31a844b1ba572167156dce05f
出典データセット
uspto-grants-1985_10
特許番号
US04546191

関連ノート

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