2,3-Dichloroquinoxaline → 2-Chloro-3-hydrazinoquinoxaline

HRID 464279

反応式

HRID 464279 の反応式
[Cl:1][C:2]1[C:11](Cl)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.O.[NH2:14][NH2:15]>C(O)C>[Cl:1][C:2]1[C:11]([NH:14][NH2:15])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 166592,3-DichloroquinoxalineHCID 24654Hydrazine hydrate (1:1)

生成物 1

HCID 36588202-Chloro-3-hydrazinoquinoxaline収率 41%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,3-Dichloroquinoxaline (33.5 g., 0.168 mole) was stirred with hydrazine hydrate (18.5 g., 0.369 mole) in 500 ml. of ethanol at room temperature overnight (i.e.. at ca. 20° C. for approximately 16 hours). The thick, yellow slurry was filtered and the precipitate was washed with ethanol. The precipitated material was recrystallized from hot methanol to give 13.5 g. (41% yield) of 2-chloro-3-hydrazinoquinoxaline, m.p. 181° C. (decomp.). Mass spectrum: m/e, 194 (P).

後処理

  1. customat room temperature
  2. customovernight (i.e.. at ca. 20° C. for approximately 16 hours)
  3. filtrationThe thick, yellow slurry was filtered
  4. washthe precipitate was washed with ethanol
  5. customThe precipitated material was recrystallized from hot methanol
  6. customto give 13.5 g

出典と根拠

ORDレコード
ord-a221652dd3ff4eb0a45c35470f69b1ee
出典データセット
uspto-grants-1985_10
特許番号
US04547501

関連ノート

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