Methane → HCID 13319896、化合物

HRID 464316

反応式

HRID 464316 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:8][CH:7]([C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)[CH2:6]2.C>C(OCCOCCOCC)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:8][C:7]([C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)=[CH:6]2

参加物

5

反応物 2

HCID 297MethaneHCID 133198953,4-Dihydro-6,7-dimethoxy-1-phenyl-3-(3-pyridyl)isoquinoline

生成物 1

HCID 13319896HCID 13319896、化合物収率 80.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8179Diethylene glycol diethyl ether溶媒

実験手順

5.0 g of 3,4-dihydro-6,7-dimethoxy-1-phenyl-3-(3-pyridyl)isoquinoline in 150 ml of diethylene glycol diethyl ether are heated at 160° C. under an atmosphere of nitrogen with 2.5 g of palladium on animal charcoal (10%) for 2.5 hours. The catalyst is filtered off, the solution is evaporated in a rotary evaporator and the residue is washed with ether. 4.0 g of the isoquinoline compound of melting point 176°-177° C. are isolated.

後処理

  1. filtrationThe catalyst is filtered off
  2. customthe solution is evaporated in a rotary evaporator
  3. washthe residue is washed with ether

出典と根拠

ORDレコード
ord-342258c5f3004a2e9040b94610ad1e0f
出典データセット
uspto-grants-1985_10
特許番号
US04547508

関連ノート

読み込み中…