HCID 12951525、化合物 → HCID 53742088、化合物

HRID 464338ノート

反応式

HRID 464338 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:6].CS[C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1>N1C=CC=CC=1>[CH3:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

参加物

4

反応物 2

HCID 12951525HCID 12951525、化合物HCID 20262876N-(3-Aminopropyl)-N-methylpyridin-2-amine

生成物 1

HCID 53742088HCID 53742088、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.98 g) and 2-methylthio-5-(4-hydroxybenzyl)pyrimid-4-one (2.48 g) were heated together under reflux in pyridine (5 ml) for 24 hr. After stripping, the residue was triturated with water (pH adjusted to 7.0 with 2N hydrochloric acid). Recrystallisation from ethanol/water and again from methanol gave 2-[3-(N-methyl-N-pyrid-2-ylamino)propyl-amino]-5-(4-hydroxybenzyl) pyrimid-4-one, 2.4 g (66%) mp 109°-11° C. (analytical sample from methanol).

後処理

  1. customthe residue was triturated with water (
  2. customRecrystallisation from ethanol/water

出典と根拠

ORDレコード
ord-a7b0736573d3426482a03bd4395dc92b
出典データセット
uspto-grants-1985_10
特許番号
US04547506

反応ノート

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