HCID 12783831、化合物 → 2-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-(5,6-dimethylpyrid-3-ylmethyl)pyrimid-4-one

HRID 464368ノート

反応式

HRID 464368 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N+](N[C:23]1[NH:28][C:27](=[O:29])[C:26]([CH2:30][C:31]2[CH:32]=[N:33][C:34]([CH3:38])=[C:35]([CH3:37])[CH:36]=2)=[CH:25][N:24]=1)([O-])=O>N1C=CC=CC=1>[CH2:6]([N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:23]1[NH:28][C:27](=[O:29])[C:26]([CH2:30][C:31]2[CH:32]=[N:33][C:34]([CH3:38])=[C:35]([CH3:37])[CH:36]=2)=[CH:25][N:24]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 12783831HCID 12783831、化合物HCID 201503642-[N-(3-aminopropyl)-N-benzylamino)pyridine

生成物 1

HCID 202628892-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-(5,6-dimethylpyrid-3-ylmethyl)pyrimid-4-one

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-[N-(3-aminopropyl)-N-benzylamino]pyridine (1 g) and 2-nitroamino-5-(5,6-dimethylpyrid-3-ylmethyl)pyrimid-4-one (0.94 g) were heated together under reflux in pyridine (5 ml) for 20 hrs. After stripping the resulting solid was recrystallized from ethanol/water to give 2-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-(5,6-dimethylpyrid-3-ylmethyl)pyrimid-4-one 0.75 H2O, 0.61 g (38%) m.p. 95°-99° C.

後処理

  1. customwas recrystallized from ethanol/water

出典と根拠

ORDレコード
ord-4974f2a97c3d4c14a9d1f882eb801b2b
出典データセット
uspto-grants-1985_10
特許番号
US04547506

反応ノート

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