6-Amino-1-cyclopropyl-5-nitroso-2,4(1H,3H)-pyrimidinedione → 1-cyclopropyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione
反応式
[NH2:1][C:2]1[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:6](=[O:11])[NH:5][C:4](=[O:12])[C:3]=1[N:13]=O>CN(C=O)C.O=[Pt]=O>[CH:8]1([N:7]2[C:2]([NH2:1])=[C:3]([NH2:13])[C:4](=[O:12])[NH:5][C:6]2=[O:11])[CH2:10][CH2:9]1参加物
4
実験手順
15.9 g of 6-amino-1-cyclopropyl-5-nitroso-2,4-(1H,3H)-pyrimidinedione (III) was catalytically hydrogenated in 1 liter of DMF and in the presence of 0.1 g PtO2 for 4 hours and at room temperature and at a pressure of 200 kPa. The catalyst and the crystals were filtered off and washed with ethanol. Yield 12.9 g (87%) (IV).
後処理
- filtrationThe catalyst and the crystals were filtered off
- washwashed with ethanol
出典と根拠
- ORDレコード
- ord-38416d6622414c3fb0ce5db55fb35fdb
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04548818
反応ノート
読み込み中…