Ammonium Chloride → 2-(2,2,2-Trifluoroethoxy)pyridin-3-amine

HRID 46466ノート

反応式

HRID 46466 の反応式
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+]([O-])=O)=[CH:7][N:6]=1.[Cl-].[NH4+:17]>[Fe].C(O)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[C:10]([NH2:17])=[CH:9][CH:8]=[CH:7][N:6]=1

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 6137185-Nitro-2-(2,2,2-trifluoroethoxy)pyridine

生成物 1

HCID 167853012-(2,2,2-Trifluoroethoxy)pyridin-3-amine収率 23.1%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 702Ethanol溶媒

実験手順

2-(2,2,2-Trifluoroethoxy)-5-nitropyridine (5.0 grams), powdered iron (15 grams), and ammonium chloride (25 grams) were refluxed in 3A ethanol until TLC detected no starting material (about 4 hours). The reaction mixture was filtered, washed with water, and solvents removed, yielding 1.0 gram of the product as a thin brownish liquid. NMR confirmed the identity of the product.

後処理

  1. customno starting material (about 4 hours)
  2. filtrationThe reaction mixture was filtered
  3. washwashed with water, and solvents
  4. customremoved

出典と根拠

ORDレコード
ord-3817a0ce2dd540c5b34efa23b714c16d
出典データセット
uspto-grants-1979_11
特許番号
US04173639

反応ノート

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