2-(Methylthio)-5-(pyridin-4-ylmethyl)pyrimidin-4(1H)-one → 2-[3-(5-Chloro-3-methylpyrid-2-ylamino)propylamino]-5-(4-pyridylmethyl)-4-pyrimidone

HRID 464685ノート

反応式

HRID 464685 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([Cl:13])=[CH:8][N:7]=1.CS[C:16]1[NH:21][C:20](=[O:22])[C:19]([CH2:23][C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)=[CH:18][N:17]=1>N1C=CC=CC=1>[Cl:13][C:9]1[CH:10]=[C:11]([CH3:12])[C:6]([NH:5][CH2:4][CH2:3][CH2:2][NH:1][C:16]2[NH:21][C:20](=[O:22])[C:19]([CH2:23][C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[CH:18][N:17]=2)=[N:7][CH:8]=1

参加物

4

反応物 2

HCID 143385852-(Methylthio)-5-(pyridin-4-ylmethyl)pyrimidin-4(1H)-oneHCID 143973652-(3-Aminopropylamino)-5-chloro-3-methylpyridine

生成物 1

HCID 202122372-[3-(5-Chloro-3-methylpyrid-2-ylamino)propylamino]-5-(4-pyridylmethyl)-4-pyrimidone収率 64%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-(3-Aminopropylamino)-5-chloro-3-methylpyridine (0.92 g) and 2-methylthio-5-(4-pyridylmethyl)-4-pyrimidone (0.90 g) were heated together under reflux in pyridine (5 ml) for 46 hr. After stripping to dryness the residue was triturated with wet ether to give a white solid. Repeated recrystallisation from isopropanol/water gave 2-[3-(5-chloro-3-methylpyrid-2-ylamino)propylamino]-5-(4-pyridylmethyl)-4-pyrimidone (0.95 g; 64%) m.p. 90°-92° C.

後処理

  1. customwas triturated with wet ether
  2. customto give a white solid
  3. customrecrystallisation from isopropanol/water

出典と根拠

ORDレコード
ord-48ef6ce081ec48cd97b233d8d8e45325
出典データセット
uspto-grants-1985_10
特許番号
US04548940

反応ノート

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