Hydrochloric Acid → 4-Nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester

HRID 464738ノート

反応式

HRID 464738 の反応式
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[CH2:6][N+:7]([O-:9])=[O:8].[C:19]([O:23][CH3:24])(=[O:22])[CH:20]=[CH2:21].Cl>C(O)(C)(C)C.C(OCC)C>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)[CH:6]([N+:7]([O-:9])=[O:8])[CH2:21][CH2:20][C:19]([O:23][CH3:24])=[O:22]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 7294Methyl AcrylateHCID 54303925Methyl 3-(4-methoxyphenyl)-4-nitrobutanoate

生成物 1

HCID 537595764-Nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6386tert-Butanol溶媒

実験手順

A solution of 200 g of 4-nitro-3-(4-methoxyphenyl)-butanoic acid methyl ester, 68 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqeous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester.

後処理

  1. customThe organic layer is separated
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-21135403639949c1a2ecac167d9e8f33
出典データセット
uspto-grants-1985_10
特許番号
US04548947

反応ノート

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