Peracetic Acid → HCID 178501977、化合物

HRID 464775ノート

反応式

HRID 464775 の反応式
C(OO)(=[O:3])C.[NH2:6][C:7]1[N:12]=[C:11]([NH:13][C:14]([O:16][CH3:17])=[O:15])[CH:10]=[C:9]([Cl:18])[N:8]=1.CCCCCC>C(Cl)(Cl)Cl>[NH2:6][C:7]1[N+:12]([O-:3])=[C:11]([NH:13][C:14]([O:16][CH3:17])=[O:15])[CH:10]=[C:9]([Cl:18])[N:8]=1

参加物

5

反応物 3

HCID 6585Peracetic AcidHCID 8058HexaneHCID 13423619Methyl 2-amino-6-chloro-4-pyrimidinecarbamate

生成物 1

HCID 178501977HCID 178501977、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

32 ml (0.20 mol) of 40% peracetic acid are added slowly to a solution of 20.2 g (0.10 mol) of methyl 2-amino-6-chloro-4-pyrimidinecarbamate in 500 ml of chloroform. The suspension obtained is warmed to 50° for 4 hours, whereby a clear solution gradually results. After cooling to room temperature, there is obtained by the slow addition of hexane a crystalline precipitate which is recrystallized from chloroform/methanol. There is obtained methyl 2-amino-6-chloro-4-pyrimidinecarbamate-3-oxide of melting point 220°-221°.

後処理

  1. customThe suspension obtained
  2. temperatureis warmed to 50° for 4 hours
  3. customwhereby a clear solution gradually results
  4. customis recrystallized from chloroform/methanol

出典と根拠

ORDレコード
ord-23dfa323923f45668afc5708e77b8c4f
出典データセット
uspto-grants-1985_10
特許番号
US04549019

反応ノート

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