Glyoxal → 1-(2,4-Dimethyl-phenyl)-3-methyl-4,5-dihydroxy-imidazolidine-2-thione

HRID 46478ノート

反応式

HRID 46478 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH:12][CH3:13])=[S:11].C[O:15][CH2:16][CH2:17][O:18]C.C(C=O)=O.NC(N)=S>C(N(CC)CC)C>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:16]([OH:15])[CH:17]([OH:18])[N:12]([CH3:13])[C:10]1=[S:11]

参加物

6

反応物 4

HCID 7860GlyoxalHCID 80711,2-DimethoxyethaneHCID 2723790ThioureaHCID 30342141-(2,4-Dimethylphenyl)-3-methylthiourea

生成物 1

HCID 203874781-(2,4-Dimethyl-phenyl)-3-methyl-4,5-dihydroxy-imidazolidine-2-thione

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

30.0 g of N-(2,4-dimethylphenyl)-N'-methyl-thiourea were stirred with 150 ml of 1,2-dimethoxy-ethane and 10 ml of triethylamine, and 36.0 g of a 30% strength aqueous solution of glyoxal was added. After stirring for a short time, the thiourea slowly dissolved, the reaction being exothermic. The temperature was allowed to rise to 50° C. and the solution was kept at this temperature for a further 1 hour. Thereafter, the solvent was distilled off in vacuo and the oily residue was stirred with water, with the addition of a little acetic acid. The reaction product, which solidified in the crystalline form, was filtered off, washed with water and dried. The yield was 37 g. For purification, the product could be recrystallised from isopropyl alcohol.

後処理

  1. additionwas added
  2. customto rise to 50° C.
  3. distillationThereafter, the solvent was distilled off in vacuo
  4. stirringthe oily residue was stirred with water, with the addition of a little acetic acid
  5. filtrationwas filtered off
  6. washwashed with water
  7. customdried
  8. customFor purification
  9. customthe product could be recrystallised from isopropyl alcohol

出典と根拠

ORDレコード
ord-7908fbcf468344a2a719f980ed193374
出典データセット
uspto-grants-1979_11
特許番号
US04173645

反応ノート

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