3-Hydroxybenzaldehyde → 3-[(3-Methylpiperidin-1-yl)methyl]phenol
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1.C(O)=O.N>O>[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:5][C:4]2[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=2)[CH2:12]1参加物
6
反応条件
- 温度
- 120 °C
実験手順
24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.
後処理
- temperaturewith cooling
- temperatureWhen the reaction mixture has cooled to room temperature
- filtrationthe precipitated solid is filtered off
- customrecrystallised from ethanol
出典と根拠
- ORDレコード
- ord-e9c53b21b5524c4296badbb52530d5b3
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04727081
反応ノート
読み込み中…