Potassium thiocyanate → HCID 20387432、化合物

HRID 46486ノート

反応式

HRID 46486 の反応式
Cl.Cl[CH2:3][CH2:4][S:5][CH2:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[CH3:12].[S-:13][C:14]#[N:15].[K+]>C(O)C>[CH3:12][C:11]1[NH:10][CH:9]=[N:8][C:7]=1[CH2:6][S:5][CH2:4][CH2:3][S:13][C:14]#[N:15]

参加物

4

反応物 2

HCID 516872Potassium thiocyanateHCID 132173611-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride

生成物 1

HCID 20387432HCID 20387432、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride (2.1 g) and potassium thiocyanate (0.97 g) were heated together under reflux in ethanol (50 ml) for 3 days. The mixture was evaporated to dryness and the residue was taken up in water, basified with sodium carbonate and extracted with chloroform. The chloroform extracts were dried (MgSO4) and evaporated to a residue which was recrystallised from acetonitrile to give 2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate m.p. 101°-103°. (Found: C, 45.3; H, 5.3; N, 19.5; S, 29.3. C8H11N3S2 requires: C, 45.0; H, 5.2; N, 19.7; S, 30.1%).

後処理

  1. customThe mixture was evaporated to dryness
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts were dried (MgSO4)
  4. customevaporated to a residue which
  5. customwas recrystallised from acetonitrile

出典と根拠

ORDレコード
ord-b01ea00b61f0449fa75b4b3db68000d8
出典データセット
uspto-grants-1979_11
特許番号
US04173644

反応ノート

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