Hydrochloric Acid → (3-Chloropyridin-2-yl)methanol
反応式
N([O-])=O.[Na+].N[C:6]1[C:7]([CH2:12][OH:13])=[N:8][CH:9]=[CH:10][CH:11]=1.[ClH:14]>O.S>[Cl:14][C:6]1[C:7]([CH2:12][OH:13])=[N:8][CH:9]=[CH:10][CH:11]=1参加物
6
実験手順
A solution of sodium nitrite (2.38 g) in water (10 ml) was added dropwise to a mixture of 3-amino-2-hydroxymethylpyridine (4.8 g), aqueous hydrochloric acid (48%, 10 ml) and water (5 ml) stirred at 0°-5°. This solution was added to a hot solution of cuprous chloride (2.5 g) in conc. hydrochloric acid and the mixture was heated on a steam-bath for 0.5 hours, diluted with water and saturated with hydrogen sulphide. The mixture was filtered, concentrated and extracted with chloroform and the chloroform extract was evaporated to give 3-chloro-2-hydroxymethylpyridine (3.7 g) m.p. 42°-44° (from n-pentane).
後処理
- temperaturethe mixture was heated on a steam-bath for 0.5 hours
- filtrationThe mixture was filtered
- concentrationconcentrated
- extractionextracted with chloroform
- extractionthe chloroform extract
- customwas evaporated
出典と根拠
- ORDレコード
- ord-d06799c8e7d2446093d305f30ce0c2ac
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04173644
反応ノート
読み込み中…