[(1-Benzylpyrrolidin-3-yl)methyl](2,2,2-trifluoroethyl)amine → (Pyrrolidin-3-ylmethyl)(2,2,2-trifluoroethyl)amine
反応式
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[F:19][C:16]([F:17])([F:18])[CH2:15][NH:14][CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1参加物
5
実験手順
A mixture of 7.15 g (26.3 mmole) 1-(phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine 100 ml of methanol and 0.7 g of 20% palladium on carbon was shaken in an atmosphere of hydrogen at about 50 psi and at room temperature for 24 hours. The catalyst was filtered and the filtrate evaporated under reduced pressure. The residue was distilled under vacuum, bp 63°-65° C. (2.8 mm), to give 2.55 g of N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine.
後処理
- filtrationThe catalyst was filtered
- customthe filtrate evaporated under reduced pressure
- distillationThe residue was distilled under vacuum, bp 63°-65° C. (2.8 mm)
出典と根拠
- ORDレコード
- ord-afe0714868cf41b0aac0057d9dd50954
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04550103
反応ノート
読み込み中…