N-((1-Benzylpyrrolidin-3-yl)methyl)propan-2-amine → N-(Pyrrolidin-3-ylmethyl)propan-2-amine

HRID 464996ノート

反応式

HRID 464996 の反応式
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH:15]([CH3:17])[CH3:16])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[CH3:16][CH:15]([NH:14][CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]

参加物

5

反応物 2

HCID 14280887N-((1-Benzylpyrrolidin-3-yl)methyl)propan-2-amineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 13491802N-(Pyrrolidin-3-ylmethyl)propan-2-amine収率 76.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 13.4 g (58.0 mmol) of 1-phenylmethyl-N-(2-propyl)-3-pyrrolidinemethanamine, 1.0 g of 20% palladium on carbon and 130 ml of methanol was shaken in an atmosphere of hydrogen at about 4.5×105Pa and room temperature for 24 hours. The catalyst was removed by filtration through Celite; the filtrate concentrated and distilled in vacuo to give 6.3 g of N-(2-propyl)-3-pyrrolidinemethanamine, mp 58°-60° C./3.5 mm.

後処理

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe filtrate concentrated
  3. distillationdistilled in vacuo

出典と根拠

ORDレコード
ord-8ada2bd3b282425e8698c35a754d4e77
出典データセット
uspto-grants-1985_10
特許番号
US04550104

反応ノート

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