2-(Morpholinomethyl)-pyridine → 4-((Piperidin-2-yl)methyl)morpholine

HRID 465050ノート

反応式

HRID 465050 の反応式
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.[Pt](=O)=O>[N:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 2696942-(Morpholinomethyl)-pyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 31633954-((Piperidin-2-yl)methyl)morpholine収率 52.2%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

First, 2-[(4-morpholinyl)methyl]pyridine (94.0 g, 0.53 mol) is dissolved in glacial acetic acid (600 ml) and hydrogenated in the presence of platinum(IV) oxide (10.0 g) as catalyst for 2 hours at a hydrogen pressure of 3 bar and a temperature of 50° C. After cooling, the catalyst is filtered off, the filtrate is freed from solvent and the residue is distilled in vacuo. The desired compound (51.0 g) is obtained in the form of a colorless liquid, boiling point 4 mm Hg 91°-92° C.

後処理

  1. customa temperature of 50° C
  2. temperatureAfter cooling
  3. filtrationthe catalyst is filtered off
  4. distillationthe residue is distilled in vacuo

出典と根拠

ORDレコード
ord-6c56b257a38d47f38fb5eebc01b1ff4f
出典データセット
uspto-grants-1985_10
特許番号
US04550107

反応ノート

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