化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiophenol → 2-(Chloromethyl)benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiophenol | HCID 8713 | — |
| 反応物 | O-methyl 2-chloroacetimidate | HCID 12680764 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(Chloromethyl)benzothiazole | HCID 304978 | 71% |
反応手順
To a solution of aminothiophenol (8.3 g) in methylene chloride at 0° C. is added methyl chloroacetimidate hydrochloride1 (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120°-135° C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04550172 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-079b659fcb014e8d9dd3b2cc8a968be4 |
| 出典メモ | uspto-grants-1985_10 |