反应详情

To a solution of aminothiophenol (8.3 g) in methylene chloride at 0° C. is added methyl chloroacetimidate hydrochloride1 (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120°-135° C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product.

1. washThe mixture is washed with water three times
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated to an oil
4. distillationThe oil is distilled (120°-135° C. at 0.5 mm Hg)