Acetic Anhydride → Thymidine, 3'-deoxy-3'-fluoro-, 5'-acetate

HRID 465303

反応式

HRID 465303 の反応式
[CH3:1][C:2]([O:4][C:5]([CH3:7])=[O:6])=O.[F:8][C@@H:9]1[C@@H](CO)[O:12][C@@H:11]([N:16]2[CH:24]=[C:22]([CH3:23])[C:20](=[O:21])[NH:19][C:17]2=[O:18])[CH2:10]1>N1C=CC=CC=1>[C:5]([O:4][CH2:2][C@H:1]1[O:12][C@@H:11]([N:16]2[CH:24]=[C:22]([CH3:23])[C:20](=[O:21])[NH:19][C:17]2=[O:18])[CH2:10][C@@H:9]1[F:8])(=[O:6])[CH3:7]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 330393'-Fluorothymidine

生成物 1

HCID 453016Thymidine, 3'-deoxy-3'-fluoro-, 5'-acetate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

56 mMol acetanhydride is added at 0° C. to a solution of 50 mMol 3'-deoxy-3'-fluorothymidine in 50 ml pyridine. The reaction solution stands overnight at room temperature and is subsequently poured into ice water. The aqueous phase is decanted. The oily product is purified in a chromatographic column on silica gel with chloroform eluent. The fractions obtained from the product are isolated as a solid material which is recrystallized from ethanol. M.P.97°-98° C.

後処理

  1. customThe aqueous phase is decanted
  2. customThe oily product is purified in a chromatographic column on silica gel with chloroform eluent
  3. customThe fractions obtained from the product
  4. customare isolated as a solid material which
  5. customis recrystallized from ethanol

出典と根拠

ORDレコード
ord-6552d41b562c4810be538d9a4db56c15
出典データセット
uspto-grants-1992_10
特許番号
US05153180

関連ノート

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