Triphenylphosphine → Diethyl [4-aminobutyl][3-(3-pyridyl)propyl]-malonate

HRID 465519ノート

反応式

HRID 465519 の反応式
[N:1]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([CH2:19][CH2:20][CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1.O>[NH2:1][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([CH2:19][CH2:20][CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 2

HCID 11776TriphenylphosphineHCID 10068124Propanedioic acid, (4-azidobutyl)[3-(3-pyridinyl)propyl]-, diethyl ester

生成物 1

HCID 10383244Diethyl [4-aminobutyl][3-(3-pyridyl)propyl]-malonate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 42.59 g (0.11 mole) of diethyl [4-azidobutyl][3-(3-pyridyl)propyl]malonate in 270 ml THF and 3.1 ml water is added 29 g (0.11 mole) of triphenyl phosphine and the solution is stirred well for 48 h. Solvent is evaporated and the residue subjected to flash chromatography to give diethyl [4-aminobutyl][3-(3-pyridyl)propyl]-malonate as an oil.

後処理

  1. customSolvent is evaporated

出典と根拠

ORDレコード
ord-a31aa1a200af4b83acd2591e41618fa4
出典データセット
uspto-grants-1992_10
特許番号
US05153214

反応ノート

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