Benzylamine → N-[2,6-bis(1-methylethyl)phenyl]-2-[phenylmethyl]amino-acetamide

HRID 465655

反応式

HRID 465655 の反応式
Br[CH2:2][C:3](Br)=[O:4].[CH:6]([C:9]1[CH:15]=[CH:14][CH:13]=[C:12]([CH:16]([CH3:18])[CH3:17])[C:10]=1[NH2:11])([CH3:8])[CH3:7].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(N(CC)CC)C>[CH3:17][CH:16]([C:12]1[CH:13]=[CH:14][CH:15]=[C:9]([CH:6]([CH3:8])[CH3:7])[C:10]=1[NH:11][C:3](=[O:4])[CH2:2][NH:26][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:18]

参加物

5

反応物 3

HCID 7504BenzylamineHCID 32484DiisopropylanilineHCID 61147Bromoacetyl bromide

生成物 1

HCID 19764427N-[2,6-bis(1-methylethyl)phenyl]-2-[phenylmethyl]amino-acetamide収率 96%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒2 回

実験手順

Bromoacetylbromide (4.5 mL) was added portionwise to a mixture of 8.85 g 2,6-diisopropylaniline and 7.0 mL triethylamine in 300 mL EtoAc at 0° C. Upon completing the addition, excess triethylamine and 5.4 g benzylamine were added and the entire mixture was heated on the steambath for 30 minutes. The reaction mixture was allowed to sit overnight at room temperature, and was then filtered, concentrated, and filtered through silica gel (70-230 mesh) using hexane/EtoAc, 1/1, as eluant. A total of 15.62 g (96%) of the title product was obtained.

後処理

  1. additionwere added
  2. temperaturethe entire mixture was heated on the steambath for 30 minutes
  3. filtrationwas then filtered
  4. concentrationconcentrated
  5. filtrationfiltered through silica gel (70-230 mesh)

出典と根拠

ORDレコード
ord-6a16c88ba0b2498c9f6d4e1a74c93659
出典データセット
uspto-grants-1992_10
特許番号
US05153226

関連ノート

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