Hydrochloric Acid → 6-ethoxy-9H-purin-2-amine

HRID 465712

反応式

HRID 465712 の反応式
[Na].[CH2:2]([OH:4])[CH3:3].[NH2:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][CH:11]=[N:12]2)=[C:8](Cl)[N:7]=1.Cl>O>[NH2:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][CH:11]=[N:12]2)=[C:8]([O:4][CH2:2][CH3:3])[N:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 53603492-Amino-6-chloropurineHCID 5360545Sodium

生成物 1

HCID 958056-ethoxy-9H-purin-2-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Sodium (0.68 g, 29.5 mmol, Aldrich lot #9621CL) was added in portions to anhydrous ethanol (50 mL). Upon complete dissolution 2-amino-6-chloropurine (1 g, 5.9 mmol Sigma lot #69F4064) was added and the reaction heated at reflux for 96 hours. The reaction was cooled, diluted with 20 mL water, and neutralized with 1N HCl. The solvents were evaporated and the residue slurried in 100 mL water. The product was filtered off and air dried to give 0.95 g (5.3 mmol; 89.9%); mp=252-°253° C.

後処理

  1. additionwas added
  2. temperaturethe reaction heated
  3. temperatureat reflux for 96 hours
  4. temperatureThe reaction was cooled
  5. customThe solvents were evaporated
  6. filtrationThe product was filtered off
  7. customair dried
  8. customto give 0.95 g (5.3 mmol; 89.9%)
  9. custommp=252-°253° C.

出典と根拠

ORDレコード
ord-708ab2843f02454bb1caa62d1a0aa4fa
出典データセット
uspto-grants-1992_10
特許番号
US05153318

関連ノート

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