Hydrochloric Acid → HCID 178458948、化合物

HRID 465714

反応式

HRID 465714 の反応式
[Na].[NH2:2][C:3]1[N:11]=[C:10]2[C:6]([NH:7][CH:8]=[N:9]2)=[C:5](Cl)[N:4]=1.Cl.[CH:14]([OH:17])([CH3:16])[CH3:15]>>[NH2:2][C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][NH:9]2)=[C:5]([O:17][CH:14]([CH3:16])[CH3:15])[N:4]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 53603492-Amino-6-chloropurineHCID 5360545Sodium

生成物 1

HCID 178458948HCID 178458948、化合物

反応条件

温度
50 °C

実験手順

Sodium (Aldrich, lot #9621CL, 4.1 g, 176.9 mmol) was reacted with 150 mL of isopropanol, 2-Amino-6-chloropurine (Sigma, lot #69F4064, 6.0 g, 35.4 mmol) was added and the reaction stirred at 50° C. for 24 hours. The solution was cooled and brought to pH 7 with 1N HCl. The solvents were evaporated to one-half volume. The precipitate was filtered, washed with water and dried to give 5.9 g (30.5 mmol, 87%); mp=204°-206° C.

後処理

  1. additionwas added
  2. temperatureThe solution was cooled
  3. customThe solvents were evaporated to one-half volume
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried
  7. customto give 5.9 g (30.5 mmol, 87%)

出典と根拠

ORDレコード
ord-5bfeec00d6244f3a9ddbde15ee195afb
出典データセット
uspto-grants-1992_10
特許番号
US05153318

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