Tetrahydrofuran → 5-Methyloxazolo[4,5-b]pyridin-2(3H)-one

HRID 465982

反応式

HRID 465982 の反応式
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[O:10]1CCC[CH2:11]1>>[CH3:9][C:4]1[N:3]=[C:2]2[NH:1][C:11](=[O:10])[O:8][C:7]2=[CH:6][CH:5]=1

参加物

3

反応物 2

HCID 8028TetrahydrofuranHCID 885002-Amino-6-methylpyridin-3-ol

生成物 1

HCID 100120755-Methyloxazolo[4,5-b]pyridin-2(3H)-one

実験手順

1.24 g (10 mmol) of 2-amino-3-hydroxy-6-methylpyridine are introduced into a three-necked round-bottomed flask. The contents are placed under argon. 20 ml of anhydrous tetrahydrofuran and then 2.43 g (15 mmol) of 1,1-carbonyldiimidazole are added. The mixture is heated to reflux for 6 hours. The reaction medium is evaporated. The crystals obtained are washed with water, filtered off and redissolved in hot methanol. The solution is filtered and re-evaporated.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 6 hours
  3. customThe reaction medium is evaporated
  4. customThe crystals obtained
  5. washare washed with water
  6. filtrationfiltered off
  7. dissolutionredissolved in hot methanol
  8. filtrationThe solution is filtered
  9. customre-evaporated

出典と根拠

ORDレコード
ord-0dfb332c095248c4ac6d13aabfae6763
出典データセット
uspto-grants-1992_10
特許番号
US05155116

関連ノート

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