Hydroxyamine hydrochloride → 6-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime

HRID 466191ノート

反応式

HRID 466191 の反応式
[O:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14]([CH:17]=O)=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22]>N1C=CC=CC=1.C(O)C>[O:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14]([CH:17]=[N:21][OH:22])=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 443297Hydroxyamine hydrochlorideHCID 149712656-phenoxy-2H-1-benzopyran-3-carboxaldehyde

生成物 1

HCID 856778336-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime

試薬・触媒・溶媒 1

HCID 21975839Pyridine ethanol溶媒

実験手順

6-Phenoxy-2H-1-benzopyran-3-carboxaldehyde (5.00 g, 19.9 mmol) is dissolved in 175 ml of pyridine/ethanol (1:1) and treated with hydroxylamine hydrochloride (2.07 g, 29.7 mmol). The mixture is stirred for 1 hour and partitioned between ether and water. The aqueous layer is extracted with ether, and the ether layer is washed with 2N HCl, dried (MgSO4) and evaporated to give 6-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime as a pale yellow solid.

後処理

  1. custompartitioned between ether and water
  2. extractionThe aqueous layer is extracted with ether
  3. washthe ether layer is washed with 2N HCl
  4. dry with materialdried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-8e53bd09a0ed4cb3af88766be1a44130
出典データセット
uspto-grants-1992_10
特許番号
US05155130

反応ノート

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