2-Chloro-1,4-naphthoquinone → 2-Methoxy-1,4-Naphthoquinone
反応式
Cl[C:2]1[C:3](=[O:13])[C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH3:14][O-:15].[Na+]>O1CCCC1>[CH3:14][O:15][C:2]1[C:3](=[O:13])[C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2参加物
4
実験手順
A solution of 2-chloro-1,4-naphthoquinone (10.3 g) in tetrahydrofuran (100 mL) was treated with a suspension of sodium methoxide (3.20 g) in tetrahydrofuran (25 mL) at room temperature. After stirring overnight, the mixture was evaporated, and the residue was taken up in ether. The organic layer was washed with brine, dried, filtered and evaporated. Chromatography over silica gel gave 2-methoxy-1,4-naphthoquinone, m.p. 182°-183° C.
後処理
- customthe mixture was evaporated
- washThe organic layer was washed with brine
- customdried
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-8900b8b807eb4e4d8e1c978df9624256
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05155132
反応ノート
読み込み中…