Benzoyl Peroxide → 6-Aminohexanoic Acid

HRID 466245ノート

反応式

HRID 466245 の反応式
BrN1C(=[O:7])CCC1=O.C[C:10]1[C:15]2[O:16]C3C(=NC=2[C:13]([C:63]([NH:65][C@@H]2C(=O)N[C@H](C(C)C)C(=O)N4[C@@H](CCC4)C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)=O)=[CH:12][CH:11]=1)C(C(N[C@@H]1C(=O)N[C@H](C(C)C)C(=O)N2[C@@H](CCC2)C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]1C)=O)=C(N)C(=O)C=3C.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>ClC1C=CC=CC=1>[CH2:12]([CH2:13][CH2:63][NH2:65])[CH2:11][CH2:10][C:15]([OH:7])=[O:16]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimide2 回HCID 457193Actinomycin D

生成物 1

HCID 5646-Aminohexanoic Acid

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

反応条件

温度
80 °C

実験手順

Bromination with N-bromosuccinimide (NBS) is accomplished by adding 2.24 mmoles of actinomycin D in chlorobenzene to 2 mmoles of NBS and a trace of dibenzoyl peroxide. The mixture is heated to 80° C. and allowed to react for 6 hours. The yield of AMD--CH2Br is 70-80%. The brominated derivative is then reacted further with aminocaprioic acid to yield an AMD-aminocaproic acid complex (AMD--CH2NH (CH2)5COOH).

後処理

  1. customto react for 6 hours
  2. customThe brominated derivative is then reacted further with aminocaprioic acid

出典と根拠

ORDレコード
ord-df38a86a642f4dd8a884cf46d0df63d0
出典データセット
uspto-grants-1992_10
特許番号
US05155210

反応ノート

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