Hydrogen Bromide → 2-Bromo-6-chloro-1-indanone

HRID 46628

反応式

HRID 46628 の反応式
[Br:1]Br.[Cl:3][C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][C:10]2=[O:13])=[CH:6][CH:5]=1.Br>C(OC(=O)C)C>[Br:1][CH:9]1[CH2:8][C:7]2[C:11](=[CH:12][C:4]([Cl:3])=[CH:5][CH:6]=2)[C:10]1=[O:13]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 51007056-Chloro-1-indanone

生成物 1

HCID 122065232-Bromo-6-chloro-1-indanone

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

A solution of 9.59 g (60.0 mmoles) of bromine in 20 ml of acetic acid ethyl ester is added dropwise to a solution of 10.0 g (60.0 mmoles) of 6-chloro-1-indanone in 80 ml of acetic acid ethyl ester and 0.5 ml of 48% strength aqueous hydrobromic acid. After stirring for 3 hours, the reaction solution is concentrated to dryness, the residue is stirred with 50 ml of water and the precipitate is filtered off. The crude product of melting point 84°-87° is recrystallized from petroleum ether 60/70 and gives the pure product of melting point 92°-94° C.

後処理

  1. concentrationthe reaction solution is concentrated to dryness
  2. stirringthe residue is stirred with 50 ml of water
  3. filtrationthe precipitate is filtered off
  4. customThe crude product of melting point 84°-87° is recrystallized from petroleum ether 60/70
  5. customgives the pure product of melting point 92°-94° C.

出典と根拠

ORDレコード
ord-840378d0473244f485c09bd95c4d779f
出典データセット
uspto-grants-1979_11
特許番号
US04174397

関連ノート

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