Oxalyl chloride → 2,6-Difluoro-4-methoxybenzoyl chloride

HRID 466489ノート

反応式

HRID 466489 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])C=1C(O)=O>C1C=CC=CC=1.CN(C=O)C>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])[C:1]=1[C:2]([Cl:4])=[O:3]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 27782282,6-Difluoro-4-methoxybenzoic acid

生成物 1

HCID 27787682,6-Difluoro-4-methoxybenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 241Benzene溶媒2 回

実験手順

A solution of oxalyl chloride (36.5 g, 0.29 mol) in dry benzene (50 ml) was added dropwise to a stirred solution of compound 24 (25.5 g, 0.14 mol) and dry DMF (40 drops) in dry benzene (500 ml) at room temperature. The mixture was stirred at room temperature overnight and the excess of oxalyl chloride and benzene were removed in vacuo.

後処理

  1. customthe excess of oxalyl chloride and benzene were removed in vacuo

出典と根拠

ORDレコード
ord-4accdac8a97c4df19fd1dc2bd631cea3
出典データセット
uspto-grants-1992_10
特許番号
US05156763

反応ノート

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