Thionyl Chloride → 2,6-Difluoro-4-methoxybenzonitrile
反応式
S(Cl)(Cl)=O.[F:5][C:6]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([F:17])[C:7]=1[C:8]([NH2:10])=O>CN(C=O)C>[F:5][C:6]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([F:17])[C:7]=1[C:8]#[N:10]参加物
4
実験手順
A solution of thionyl chloride (139.0 g, 1.17 mol) in dry DMF (150 ml) was added to a stirred solution of compound 26 (20.0 g, 0.11 mol) in dry DMF (250 ml) at room temperature. The mixture was stirred at room temperature overnight and then poured onto ice-water. The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, saturated sodium hydrogen carbonate, water and dried (MgSO4). The solvent was removed in vacuo to give off-white crystals.
後処理
- additionpoured onto ice-water
- extractionThe product was extracted into ether (twice), and the combined ethereal extracts
- washwere washed with water, saturated sodium hydrogen carbonate, water
- dry with materialdried (MgSO4)
- customThe solvent was removed in vacuo
- customto give off-white crystals
出典と根拠
- ORDレコード
- ord-ec772511e3f64619a63fe8ef27fddd87
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05156763
反応ノート
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