2-(4-Bromophenyl)thiophene → 2-(p-Bromophenyl)-5-(m-nitrophenylthio)thiophene

HRID 46650ノート

反応式

HRID 46650 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]Cl)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[Br:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[CH:15][CH:14]=1>C(Cl)(Cl)(Cl)Cl.[Fe]>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[S:20][C:21]([S:10][C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)=[CH:22][CH:23]=2)=[CH:17][CH:18]=1

参加物

5

反応物 2

HCID 70182982-(4-Bromophenyl)thiopheneHCID 156206861-(Chlorosulfanyl)-3-nitrobenzene

生成物 1

HCID 203866592-(p-Bromophenyl)-5-(m-nitrophenylthio)thiophene収率 44%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 21.2 g (0.112 mole) of m-nitrobenzenesulfenyl chloride in 160 ml of carbon tetrachioride were added 24.5 g (0.103 mole) of 2-(p-bromophenyl)thiophene and 0.1 g of iron powder. The reaction mixture was allowed to stand one week at room temperature. Evaporation of the solvent and recrystallization of the residue from 140 ml of ethyl acetate gave 17.6 g (44%) of 2-(p-bromophenyl)-5-(m-nitrophenylthio)thiophene, m.p. 120°-122° C.

後処理

  1. waitto stand one week at room temperature
  2. customEvaporation of the solvent and recrystallization of the residue from 140 ml of ethyl acetate

出典と根拠

ORDレコード
ord-362563c75c84490c9f528892d920a28b
出典データセット
uspto-grants-1979_11
特許番号
US04174405

反応ノート

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